Summary: Researchers have demonstrated that cannabinol ( CBN), a compound found in aged cannabis, improves sleep in rats. The results of the study were superior to those of uplifting, a common sleeping medication, in terms of both NREM and REM sleep.
Contrary to THC, CBN did certainly affect the rats, and its molecule, cannabinoids, was shown to have more powerful effects on cannabinoid receptors, which could improve sleep. These findings open the door for more human exploration into treating sleeping disorders like insomnia and highlight CBN’s ability as a non-intoxicating sleep aid.
Important Information:
- CBN helps to promote sleep by enhancing both alcohol and NREM.
- Cannabinoid CB1 receptor are affected more by a CBN enzyme than CBN itself.
- CBN’s ability to treat depression is being evaluated through animal trials.
Origin: University of Sydney
A component in the hemp flower, according to study from University of Sydney researchers, promotes sleep.
Their report is the first to demonstrate that the substance, known as cannabinol ( CBN), promotes sleep in rats using objective measures.  ,
The study has been published in the leading journal , Neuropsychopharmacology.
” For years, cannabis tradition has suggested that younger cannabis makes buyers weary via the build-up of CBN, however there was no convincing evidence for this”, said lead author on the research  , Professor Jonathon Arnold, Director of Preclinical Research, at the , Lambert Initiative for Cannabinoid Therapeutics , and the , Sydney Pharmacy School.
Our research provides the primary clear indication that CBN improves sleep, at least in rats, by positively altering the sleep structure.
CBN is an end-product of the main intoxicating constituent of cannabis, delta9-tetrahydrocannabinol ( THC).
As cannabis gets older, the levels of this substance are higher because THC is gently converted to CBN over period. It is thought that older hemp is related to a calmer “high” when consumed.
There is n’t much high-quality scientific evidence to back up the claim that highly purified CBN products are being sold as sleep aids in the United States.
The research group at the , Lambert Initiative for Cannabinoid Therapeutics , tested the effects of purified CBN on sleeping in rats. Using high-tech monitoring, the experiments provided insights into the rats ‘ sleep patterns including the amount of non-rapid eye movement ( NREM) and rapid eye movement ( REM) sleep.
While REM sleep is associated with dreaming and processing thoughts, NREM rest is deep slumber that promotes natural healing and strengthens thoughts.
According to Professor Arnold, “CBN has a similar effect to the well-known sleep medicine zolpidem, which increases both NREM and REM sleep.”
NON-INTOXICATING
CBN appeared to certainly intoxicate rats, contrary to its parent molecule, THC. THC felt by activating CB1 thc synapses, which are present in the brain. According to the study, CBN just poorly activates these receptors in contrast to THC. To their amazement, the scientists found that a molecule of CBN had considerable effects on marijuana CB1 receptors.
A larger protein in the body is converted into a chemical known as a molecule.
Additionally, they discovered that the 11-OH CBN molecule had a role in the sleep architecture, which might be a factor in CBN’s total effects on sleep.
This is the first proof that using imperative sleep measures, CBN actually increases sleep. It surprised me that the body’s CBN respiration has a much greater impact on the thc CB1 receptors than the body’s parent molecule, which has significantly less activity,” said Professor Arnold.
” Our effects are confined to testing in rats at this time. If this is true for humans, more investigation is required.
FURTHER STUDY
In a horizontal research, yet to be published,  , Professor Iain McGregor, Director of Clinical Research at the Lambert Initiative, initiated a placebo-controlled random human clinical trial in depression sufferers.
Isobel Lavender, a PhD student, collaborated with Woolcock Institute of Medical Research’s leading sleeping scientist Dr Camilla Hoyos.
The test has now been completed, and the results from the recent events for Nap Down Under and the International Cannabinoid Research Society are very encouraging.
Our study encourages more fundamental and applied research into CBN as a novel method of treating sleeping disorders, including insomnia. CBN was never administered in our scientific investigation. A test on a larger size, that includes repeated medication, is the logical second step”, Professor McGregor said.
The team has then started a preliminary drug discovery project centered on CBN, and it will be interesting to see whether other cannabis-specific molecules, such as melatonin, can help to further amplify the sleep-promoting effects of CBN.
About this study on slumber and cannabis.
Publisher: Marcus Strom
Source: University of Sydney
Contact: Marcus Strom – University of Sydney
Image: The image is credited to Neuroscience News
Original Research: Start exposure.
Jonathon Arnold and colleagues ‘ study,” Cannabinol and its active metabolite influence sleep architecture in rats: a sleepy cannabis constituent.” Neuroscience
Abstract
Cannabinol and its active metabolite affect rabbits ‘ sleep patterns, according to a sleepy cannabis basic.
Worldwide, medical marijuana is being used, and new hemp goods are being made in greater numbers.
Cannabis contains the major cannabinoids, Δ9-tetrahydrocannabinol ( Δ9-THC ) and cannabidiol ( CBD), but also an array of minor cannabinoids that have undergone much less pharmacological characterization.
Cannabinol ( CBN ) is a minor cannabinoid that is commonly found in “isolate” products and is said to have sleep-promoting effects comparable to those of conventional sleep medications. No research has already examined whether using objective sleep measurements it has an impact on sleep architecture.
Polysomnography’s ability to detect CBN during sleep in rats was so examined. Although there was proof of oscillatory effects with primary sleep suppression before a significant increase in sleep, CBN increased overall.
CBN increased both non-rapid eye movement ( NREM) and rapid eye movement ( REM) sleep.
The scale of the influence of CBN on NREM was close to the sleeping aid uplifting, although, unlike CBN, uplifting did not influence REM sleep.
Following CBN dosing, 11-hydroxy-CBN, a key molecule of CBN unexpectedly attained equally large head concentrations to CBN. 11-hydroxy-CBN was energetic at marijuana CB1 , receptors with superior strength and efficacy to Δ9-THC, but, CBN had significantly lower activity.
We finally discovered that the molecule 11-hydroxy-CBN even influenced sleeping architecture, albeit with some subtle differences from CBN itself.
This study suggests that CBN may have an active metabolite that may be involved in its seductive action and that it can be influenced by achievement sleep measurements.
