Summary: New research has revealed that people who have type 2 diabetes are more likely to develop memory, especially those who are obese, at a younger years. According to the study, dementia risk increases by 1.9 % for each year before type 2 diabetes is diagnosed.
The highest memory rates were found in those who had diabetes before they were 50, adding to this threat. These findings emphasize the need for qualified treatments to stop cognitive decline while managing both diabetes and obesity.
Important Information:
- Before the age of 50, type 2 diabetes patients diagnosed before the age of 70 or older are nearly twice as likely to produce delirium.
- In younger people with diabetes, obesity significantly increases the risk of memory.
- For each year earlier type 2 diabetes is diagnosed, dementia risk rises by 1.9 %.
Origin: NYU
According to a study led by researchers at NYU Rory Meyers College of Nursing, those who are diagnosed with type 2 diabetes at a younger years are more likely than those who are diagnosed later in life.
The results,  , published in , PLOS ONE,  , demonstrate that the increased risk is particularly pronounced among people with fat.
According to Xiang Qi, associate professor at NYU Meyers and article’s first writer, “our research suggests that there may be mental repercussions for earlier onset type 2 diabetes,” and it underscores the need for dementia prevention methods that take into account both diabetes and obesity.
Type 2 diabetes is a known risk factor for dementia. Although the main methods are not completely understood, scientists think that some of the marks of diabetes—such as high blood sugar, insulin resistance, and inflammation—may encourage the development of memory in the mind.
One in five individuals with type 2 diabetes worldwide are under the age of 40, which makes it a condition that was once confined to older people.
The analysis team analyzed data from the University of Michigan Institute for Social Research’s Health and Retirement Study, a longitudinal study, to know how dementia risk is impacted by a type 2 diabetes treatment.
The PLOS ONE review included 1, 213 U. S. individuals aged 50 and over with type 2 diabetes confirmed by blood testing —and no delirium upon joining the investigation. Following participants for up to 14 years, 216 ( 17.8 % ) developed dementia based on follow-up telephone interviews.
The scientists discovered that people who had type 2 diabetes at younger ages had a higher risk of developing memory than those who had it diagnosed at a senior age.
Adults who had diabetes before the age of 50 had a 1.9 percent higher risk of dementia than those who had it in their 70s and older, while those who had it between 50 and 59 years were 1.72 times as good, and those who had it between 60 and 69 years were 1.7 times as likely.
The researchers found a graded correlation between dementia risk and age at diagnosis: for every year a person is diagnosed with type 2 diabetes, their risk of dementia increases by 1 %.
While it’s unknown why a diagnosis of diabetes earlier raises the risk of dementia, previous research suggests that people who are diagnosed with type 2 diabetes in the middle of life may have more vascular problems, poor blood sugar control, and hormone resistance, all of which are known risk factors for mental impairment, according to Bei Wu, the senior author of the study and NYU Meyers ‘ top researcher.
In contrast, obesity appeared to influence the connection between type 2 diabetes and memory. In the study, those who had type 2 diabetes before they were 50 years old and had obesity were the most likely to have memory.
The researchers note that more comprehensive research on the link between obesity, diabetes, and delirium may help determine the most effective preventive measures.
Our study highlights the significance of a person’s age when they are diagnosed with diabetes and suggests that particularly addressing obesity, whether through diet, exercise, or maybe medication, may help prevent dementia in younger adults with diabetes, Wu said.
In addition to Qi and Wu, research artists include Zheng Zhu of NYU Meyers, Huabin Luo of East Carolina University, and Mark D. Schwartz of NYU Grossman School of Medicine.
Funding: The research was supported in part by the National Institute of Aging ( P30AG083257, R56AG067619 ) and National Institute of Minority Health and Health Disparities ( P50MD017356 ).
About this study on diabetes and delirium
Author: Rachel Harrison
Source: NYU
Contact: Rachel Harrison – NYU
Image: The image is credited to Neuroscience News
Original Research: Start exposure.
” Age at diagnosis of diabetes, obesity, and the risk of memory among adult patients with type 2 diabetes” by Xiang Qi et cetera. PLOS One
Abstract
Age at diagnosis of diabetes, obesity, and the risk of memory among adult patients with type 2 diabetes
Background
Few studies have examined how age at diagnosis of diabetes ( T2DM) affects dementia risk in diabetic populations, despite the rising prevalence of Type 2 diabetes in younger people. We wanted to find out whether fat modifies this connection and whether time at the T2DM diagnosis increases the risk of dementia.
Methods
We conducted a prospective cohort study using data from the Health and Retirement Study ( 2002–2016 ) matched with its 2003 Diabetes Mail-Out Survey. The research included 1, 213 dementia-free people aged ≥50 with detected T2DM. Primary exposures were age at T2DM diagnosis ( categorized as <, 50, 50–59, 60–69, and ≥70 years ) and obesity status ( BM I ≥30 kg/m2 ).
The phone interview for mental status was used to determine the outcome of the diagnosis of incident dementia. Cox proportional hazards models were used to estimate hazard ratios ( HRs ) and 95 % confidence intervals ( CIs ), adjusting for sociodemographic factors, health behaviors, health status, and diabetes medication use.
Results
Over a median follow-up of 10 ( interquartile range, 6–14 ) years, 216 ( 17.8 % ) participants developed dementia. Compared to participants diagnosed with T2DM at age ≥70 years, those diagnosed at younger ages had increased dementia risk: HR 1.70 (95 % CI, 1.03–2.80 ) for 60–69 years, 1.72 (95 % CI, 1.06–2.79 ) for 50–59 years, and 1.90 (95 % CI, 1.14–3.18 ) for <, 50 years.
Obesity significantly moderated this relationship, with obese individuals diagnosed with T2DM before age 50 showing the highest dementia risk ( HR 3.05, 95 % CI 1.23–7.56 ) compared to non-obese individuals diagnosed at ≥50 years.
Conclusions
A higher risk of memory was considerably related to a person’s younger age, especially those who had obesity. For adults with T2DM who have a younger beginning, interventions that specifically target fat may be more effective at preventing dementia.
