Summary: New research shows that intermittent fasting, while beneficial for metabolic health, may slow hair regrowth by impairing hair follicle stem cells ( HFSCs ). Fasting caused HFSCs to go into death during prolonged fasting periods in animals as a result of reactive stress and free fatty acid accumulation.
A small scientific test suggested a time-restricted diet had a lighter effect on people, with an 18 % slowdown in hair growth rate. Antioxidants like acid E reduced the detrimental effects on HFSCs, presenting possible remedies for atténuating these undesirable effects.
Major Information
- Stem Cell Stress: Fasting raises free fatty acids near hair follicle, triggering HFSC death.
- People Impact: An 18 % reduction in hair growth rate was observed during fasting in people.
- Oxidative Role: Vitamin E and increased oxidative power protect HFSCs from fasting-induced injury.
Origin: Cell Press
Although intermittent fasting has been shown to improve physiological health, a new study found that it could, at least in animals, slow down hair growth.
Researchers statement that mice exposed to intermittent fasting governments had better metabolic health but slower hair renewal than animals with 24/7 food access.
Based on a little clinical trial the group also conducted, it’s possible that people will go through a similar process, but it’s likely to be less severe because people have different hair growth trends and a little slower metabolic level than animals.
It’s important to be aware that intermittent fasting may have some unexpected results, according to senior author and plant cell biologist Bing Zhang of Westlake University in Zhejiang, China.
Previous studies have demonstrated that fasting can reduce the stress tolerance of stem cells in blood, intestinal, and muscle cells, but little is known about how it affects external cells like skin and hair. The research conducted by Zhang’s team suggested that fasting could even help with skin tissue regeneration, which replaces damaged and aging cells.
To check this, they examined the regrowth of hair in mice that had been shaved before being subjected to various continuous eating regimens. While some mice were fed on an alternate-day feeding ( ADF) schedule that included 8 hours of food access and 16 hours of fasting each day, some mice were fed on a time-restricted feeding ( TRF ) schedule.
They discovered that eating prevented hair regeneration. Compared to control mice that had no access to food and had no access to food, rabbits on both intermittent fasting periods showed even partial hair regrowth after 96 time.
The team discovered that this prevented hair growth because HFSCs are unable to deal with the reactive stress brought on by switching from sugar to large. HFSCs go through various stages of action and slumber, and scalp regrowth depends on the activity of these tissues.
The HFSCs of the control mice started to become activated around day 20 after shaving, and they remained energetic until their hair regrew. However, during extended fasting times, the activated HFSCs underwent death ( programmed cell death ).
The staff demonstrated using genetic engineering techniques that this fasting-induced death was caused by a higher concentration of free greasy acids close to the hair follicles, which resulted in a build-up of dangerous radical oxygen types within the HFSCs. Free fatty acid also caused people HFSCs to have apoptosis , in vivo.
” During fasting, adipose tissues starts to release free fatty acids, and these fatty acids enter the HFSCs that were just activated, but these stem cell don’t have the right technology to apply them”, says Zhang.
In contrast, cutaneous stem cells, which are responsible for maintaining the epidermal body barrier, were intact by intermittent fasting. Epithelial stem cells have a higher antioxidant power than these plant cell types, which is their main distinguishing characteristic.
When the team examined whether antioxidants could counteract the effects of fasting on hair growth, they discovered that HFSCs survived the fast by applying topical vitamin E and undergoing hereditary overexpression of antioxidant power.
Additionally, the group conducted a small clinical trial with 49 good young people to find out whether eating has any similar impact on human hair regrowth. Given the study’s small sample size and brief duration ( 10 days ), larger studies would be required to verify this effect. A time-restricted diet involving 18 hours of fasting per day reduced the average speed of hair growth by 18 % compared to controls.
” The human people is very diverse, so the results may be different for various people”, says Zhang.
According to the authors, animals also have a pretty high metabolic rate when compared to humans, so sleeping and metabolic changing have a more significant impact on rat HFSCs. We see a lighter effect in humans—there are also apoptotic stem cells, but some HFSCs survive. But, there is still hair regeneration, it’s just a little bit slower than usual”.
In upcoming research, the researchers intend to work with local facilities to determine how eating affects other body and other system system types of stem cells.
We intend to analyze how this process influences other organs ‘ renewal processes, Zhang says.
We also want to understand how eating affects the treatment of skin wounds, as well as discover metabolites that might encourage HFSC survival and encourage hair growth while fasting.
Funding:
The Westlake Laboratory of Life Sciences and Biomedicine, the Research Center for Industries of the Future (RCIF), the Center for Synthetic Biology and Integrated Bioengineering at Westlake University, the National Natural Science Foundation of China, Zhejiang’s Essential R&, D Program, and the National Natural Science Foundation of China.
About this information about genetics analysis and intermittent fasting
Author: Kristopher Benke
Source: Cell Press
Contact: Kristopher Benke – Cell Press
Image: The image is credited to Neuroscience News
Original Research: Start entry.
Bing Zhang and colleagues ‘ paper,” Continuous Fasting Causes Interorgan Communication to Stop Hair Follicle Renewal,” is available online. Cell
Abstract
Continuous Fasting Causes Interorgan Communication to Stop Hair Follicle Renewal
Intermittent fasting has gained widespread acceptance for its potential wellness benefits, but its effect on bodily stem cells and tissue science is still a mystery.
We report here that frequently practiced intermittent fasting regimens selectively induce apoptosis in activated hair follicle stem cells ( HFSCs ).
This consequence is independent of calorie reduction, daily rhythm modifications, or the mTORC1 mobile nutrient-sensing system.
Instead of causing oxidative damage and apoptosis, fasting activates crosstalk between the adrenal glands and dermal adipocytes in the skin. This causes the rapid release of free fatty acids into the niche, which in turn disrupts HFSCs ‘ normal metabolism and raises their levels of reactive oxygen species ( ROS), leading to oxidative damage and apoptosis.
A randomized clinical trial (NCT05800730 ) indicates that intermittent fasting inhibits human hair growth.
Our investigation discovers an inhibitory influence of intermittent fasting on muscle regeneration and discovers interorgan communication that stops tissue regeneration during periods of inert mineral supply and removes activated HFSCs.
