Summary: The effect of dopamine on serotonin in the brain properly explain the differences between intercourse in neurological conditions like Tourette syndrome, schizophrenia, and ADHD. A new keyboard study has discovered that the feminine response to histamine is influenced by the estrous cycle but that males do not decrease dopamine but that females do it more.
Additionally, researchers discovered that the mechanisms by which serotonin regulates serotonin vary among sexes. These findings point to the potential for personal therapies that can target serotonin receptors more effectively in these situations.
Important Information
- Sex-Specific Results: Serotonin increases serotonin levels in females but decreases it in males.
- Dopamine response in females differs with the estrous period.
- Treatment Potential: Sex-based dopamine receptor targeting does increase TS, ADHD, and dementia results.
Origin: SfN
Sex differences with unknown mechanisms are present in conditions like Tourette syndrome ( TS), schizophrenia, and Attention-Deficit/Hyperactivity Disorder ( ADHD).
These sex-specific methods may aid in the development of more potent therapies.
Meghan Van Zandt and Christopher Pittenger used mice to explore the underlying gender differences in these medical conditions in a recent article in the journal of neuroscience.  ,
Prior to this study, the scientists were aware that these neurological conditions are caused by changed serotonin signaling in the same mental system.
Also, human genetic studies have suggested that a natural substance called histamine may be involved in dysregulating dopamine signaling, which could explain at least TS.
Van Zandt and Pittenger therefore examined sexual differences in how dopamine and serotonin interact in this mind network.  ,  ,
The scientists discovered that histamine had different effects on serotonin levels in males and females by manipulating dopamine signaling in animals. This result was influenced by the estrous period in women.
Additionally, the researchers discovered sexual differences in the ways that serotonin regulated serotonin levels.  ,  ,
This study, in the authors ‘ opinion, may influence the development of treatment options, implying that sex-specific therapies targeting various serotonin receptors can successfully correct TS, dementia, and ADHD dopamine signaling.  ,  ,  ,
About this study news article on serotonin and sex differences
Author: SfN Media
Source: SfN
Contact: SfN Media – SfN
Image: The image is credited to Neuroscience News
Original Research: Disclosed exposure.
Meghan Van Zandt , et cetera.,” Sex Distinctions in Histamine Regulation of Striatal Dopamine.” Journal of Neuroscience
Abstract
Sexual Differences in Striatal Dopamine Serotonin Regulation
Male and female dopamine levels in the basal ganglia vary, and this is linked to a number of neuropsychiatric conditions, including some, like Tourette Syndrome ( TS ) and attention deficit hyperactivity disorder ( ADHD), which have marked sex differences in prevalence.
Biological research in TS and later animal research indicate that a reduction of serotonin may cause dopamine to be dysregulated.
We used microdialysis, targeted pharmacology, and shRNA knockdown to characterize the dopamine receptors ‘ striatal serotonin modulation as a result.
In male mice, intraventricular ( ICV ) histamine reduced striatal dopamine, a step backwards in previous research. In comparison, ICV serotonin, which is unanticipated, increased female striatal dopamine.
The substantia nigra pars compacta ( SNc )’s H2R receptors are dependent on ICV or a targeted infusion of agonists, according to research on ICV.
The result was obviated by SNc GABAergic neurons ‘ H2R knockout, making these cells the most important site for histamine-dependent dopamine regulation in males.
H2R in women, however, was largely unobserved; rather, H3R receptors in the brain increased striatal dopamine.
The estrous routine, which only occurs in estrus/proestrus when hormone levels are high, was remarkably modulated in women.
These findings demonstrate that serotonin is used to regulate striatal serotonin, but they also show that this result is markedly different from and subject to estrous modulation.
These findings may provide some insight into the molecular basis for sexual differences in striatal circuitry and in a number of psychiatric conditions.
