Summary: A significant research in Sweden has discovered that people with dementia are significantly more likely to develop early-onset Parkinson’s disease. Researchers studied more than two million people and found that those who had autism were four times more likely than those who had dementia before they were 50 years old.
The association may be brought on by a number of dopamine-related mind systems, which are involved in both social and physical habits. Even after accounting for aspects like medication use and psychological illness, the threat remained noticeably higher, suggesting a potential biological clash.
Important Information
- Increased Chance: Autistic people are four times more likely to produce early-onset Parkinson’s disease.
- Probable Link: Dopamine method function may be the cause of both circumstances.
- Frequent Association: Despite taking into account medications and emotional health factors, risk continues to double.
Karolinska Institute is the cause.
A large-scale research from the Karolinska Institutet, published in the journal JAMA Neurology, found that those with autism are more likely to develop Parkinson’s disease later in life. The researchers think that the two conditions may have underlying biological methods.
The study is based on registration records from more than two million people who were born in Sweden between 1974 and 1999 and who were followed from the age of 20 until the year 2022.
The researchers examined a possible link between the neuropsychiatric diagnosis Autism Spectrum Disorder ( ASD ), which affects an individual’s behavior, interpersonal communication, and early-onset Parkinson’s disease, a condition that affects locomotion and movement.
Dopamine may be a source of the problem.
The findings reveal that those who received an autism diagnosis were four times more likely than those without it to develop Parkinson’s disease. This was true even after controlling for social position, a genetic predisposition to mental condition or Parkinson’s disease, and other such elements.
Weiyao Yin, the article’s first author and scholar at the Karolinska Institutet’s Department of Medical Epidemiology and Biostatistics, says,” This suggests that there can be shared natural drivers behind ASD and Parkinson’s disease.”
” The brain’s serotonin system may be affected in both cases, given that the neurotransmitter serotonin is crucial for social behavior and activity control,” one theory suggests.
Dopamine-producing cells are well known to be degraded in Parkinson’s disorder. Dopamine may be a factor in dementia, but past studies have also shown this, but more research needs to be done to verify this.
Dr. Yin says,” We hope that our findings will finally help clarify the underlying factors of both ASD and Parkinson’s disease.”
Health examinations are crucial.
Antipsychotic drugs, which are known to be able to cause Parkinson ‘s-like symptoms, are common in people with autism, as are depression and the use of antidepressants.
The relationship between ASD and the early development of Parkinson’s condition was less significant after these factors were adjusted by the researchers, but the risk was also triple.
The experts point out that the study’s participants were 34 years old on average and that they were only able to identify early-onset Parkinson’s illness before the age of 50. So, Parkinson’s disease had a very low occurrence. If the increased danger persists into older age, coming studies will need to be conducted.
Sven Sandin, the study’s final author, researcher and epidemiology at the Karolinska Institutet, states that” the healthcare providers need to keep people with ASD, a defenseless group with higher co-morbidity and a high usage of psychotropics, under long-term observation.”
It’s also important to keep in mind that a Parkinson’s treatment before the age of 50 is quite uncommon, even for those who have autism.
The research received a majority of its revenue from the Swedish Research Council and the Simons Foundation.
Two scholars have denied providing any financial support to the research from pharmaceutical companies. Consult the published article for more details on potential conflicts of interest.
About this study on dementia and Parkinson’s condition
Author: Press Office
Source: Karolinska Institute
Contact: Press Office – Karolinska Institute
Image: The image is credited to Neuroscience News
Original Research: Private entry.
Weiyao Yin and colleagues ‘” Threat of Parkinson Disease in People With Autism Spectrum Disorder.” Neurology JAMA
Abstract
People with autism spectrum disorder have a higher risk of developing Parkinson condition.
Importance
Recent research points to a mute biological connection between Parkinson disease ( PD ) and autism spectrum disorder ( ASD ). However, there aren’t many big vertical experiments that examine the risk of PD following ASD.
Objective
to verify the link between PD threat in the future and ASD.
Design, Setting, and Participants;
Data from Finnish national files were used to conduct a nationwide population-based possible cohort study. All people who were born in Sweden between 1974 and 1999 were taken into account, followed by a follow-up period of 20 years until December 31, 2022, and had full covariate data. In August of this year, 2024, the study was finished.
Exposures
ASD as a time-varying contact is identified using the National Patient Register.
Main Results and Measures  ,  ,
Through 2022, the National Patient Register provided PD symptoms. Using incidence rate ratios with 95 % confidence intervals ( CI) from Poisson regression, the relative risk ( RR ) of PD was determined. Preterm delivery, depression, opioid use, and time-related psychotic exposure had the potential to alter life events.
Results
The research included 2 278 565 people ( median]IQR] years at return, 34]29-42] ages, 1 106 772 female]48.6 % ] ), contributing 33 858 476 person-years. PD occurred in 438 of 2 226 611 individuals without ASD ( 0.02 %, 1.3 cases/100 000 person-years ) and 24 of 51 954 individuals with ASD ( 0.05 %, 3.9 cases/100 000 person-years ) ( RR, 4.43]95 % CI, 2.92-6.72] ).
After accounting for gender, social status, family history of mental illness, household background of PD, and age at the diagnosis of ASD, the risk estimates were comparable. Premature or early-term conception was not related to or affected the PD risk. Depression and antidepressant use ( present in 24 257 individuals with ASD]46.7 % ] ) were associated with increased risk of PD ( RR, 2.01]95 % CI, 1.40-2.88] ), independent of ASD.
Antipsychotic exposure ( present in 16 387 people with ASD]31.5 % ] ) reduced but did not completely attenuate the association ( RR, 2.00]95 % CI, 1.27-3.14] ) and demonstrated no link between ASD and PD risk.
Conclusions and Relevance  , ,
Even after adjustment for depression, antidepressant use, and psychotic exposure, ASD was linked to an increased risk of developing PD. These results point to a possible link between developmental disorders and PD, and it may be appropriate to raise awareness of long-term neural conditions in those who have ASD.
