Summary: In a preliminary study, Psilocybin, an effective compound made from psychedelic mushrooms, significantly delayed mobile aging and extended life. Researchers found a 50 % longer lifespan for human skin and lung tissue and a 30 % longer survival rate for aging mice treated with psi.
The substance appeared to help speed up aging, protect telomeres, and speed up DNA repair, which were all important factors. These studies suggest that mushroom may one day improve both longevity and quality of life in aging groups.
Important Information
- Cellular Longevity: Psilocybin increased the duration of human tissues by more than 50 %.
- Improved Aging in Mice: Treated aged animals lived 30 % longer and had better physical characteristics.
- Benefits identified by mechanisms linked to decreased anxiety, DNA repair, and chromatin protection.
Origin: Emory University
Emory University experts discovered a substance that constantly delays aging in cells and organisms as income from the anti-aging business, which is riddled with desire and thousands of products, rose past$ 500 million next year.  ,
A recently published study in Nature Partner Journals ‘ , Aging , shows that consuming psilocin, the active ingredient in psychedelic mushrooms , , increased the cellular lifespan of human skin and lung cells by more than 50 %.  ,
The second long-term, in vivo study evaluating the structural effects of psilocybin was conducted in parallel with the researchers who conducted the same study. It was done in mice that were 19 months old, or the equivalent of 60 to 65 years old.  ,
Results showed that animals with a 5 mg preliminary low dose of psilocybin and a 15 mg monthly high dose for 10 months, as well as animals without, had a 30 % better chance of survival. Additionally, these mice had better natural characteristics, like better leather quality, fewer white hairs, and hair growth.  ,
This research suggests that psilocybin, which has been traditionally studied for its mental health benefits, reduces oxidative stress, improves DNA repair replies, and preserves chromosomal length, among other marks of aging.
The organized ends of a gene are known as telomeres , protecting it from harm that may cause the development of age-related illnesses like cancer, neurodegeneration, or cardiovascular disease. These fundamental factors influence animal aging and the beginning of these serious diseases.
Psilocybin may have the potential to revolutionize anti-aging treatments and become a potent involvement in an aging population, according to the study’s findings.  ,
This study provides a new insight into how widespread aging operations, especially when administered later in life, are affected by the presence of dopamine receptors in the body, according to Louise Hecker, PhD, senior author on the research and former affiliate teacher at Emory University, where the study was initiated and funded.  ,
Several studies have examined the structural effects of psilocybin, despite the vast majority of what researchers are aware of. Although mushroom is frequently associated with psychedelic effects, the majority of body cells have serotonin receptors.  ,
” Our study raises fresh concerns about the potential benefits of long-term procedures. Furthermore, even when the intervention is initiated in mice late in life, it also leads to improved survival, which is clinically relevant for healthy aging, adds Hecker, who is a professor presently an associate professor at Baylor College of Medicine.  ,
This announcement follows KFF’s most recent report, which revealed that the U.S. life lifespan is still below that of other nations with comparable income and size, with an average lifespan of 78.4 ages, compared to 82.5 years abroad. The duration in similar places increased by 7.9 times between 1980 and 2022, while the U.S. life expectancy has only increased by 4.7 times.  ,
According to Director of Psychedelic Research at Emory University’s Department of Psychiatry Ali John Zarrabi, MD,” This study provides solid preliminary evidence that psilocybin does contribute to healthier aging—not simply a longer lifespan, but a better quality of life in later years.”
One of my biggest problems as a preventative care physician-scientist is prolonging life at the expense of respect and performance. However, these animals were not just surviving longer; they also experienced better aging, says Zarrabi, the study’s co-investigator.  ,  ,
Zarrabi emphasized the need for more studies in older people as well as the well-known relationship between physical and mental health.  ,
According to Zarrabi,” Emory is actively involved in Phase II and III clinical studies of psilocybin-assisted treatment for despair,” and these results suggest that we also need to know psilocybin’s widespread results in aging populations.
” My hope is also that if psilocybin-assisted therapy is approved by the FDA as an intervention for depression in 2027, having a better quality of life would also translate into a longer, healthier life.”
Funding: The study was started at Emory University and was supported by a number of awards, including the Emory University School of Medicine’s Imagine, Innovative, and Impact ( I3 ) Award, Georgia CTSA NIH Award, and a grant from Emory’s Woodruff Health Sciences Center for Health in Aging.
About this news from the field of psychopharmacology and longevity
Author: Lara Moore
Source: Emory University
Contact: Lara Moore – Emory University
Image: The image is credited to Neuroscience News
Open access to original research
Louise Hecker and colleagues ‘ study” Psilocybin treatment increases cellular lifespan and improves survival in older mice..” npj Aging
Abstract
Psilocybin treatment increases cellular lifespan and improves survival in older mice.
Due to strong clinical support for its therapeutic potential in treating a variety of psychiatric and neurodegenerative indications, Psilocybin, a naturally occurring psychedelic compound created by hallucinogenic mushrooms, has attracted attention.
However, the molecular mechanisms that underlie it remain unclear, and few studies have looked at its systemic effects.
We provide the first experimental proof that psilocin ( the active metabolite of psilocybin ) treatment prolongs cellular lifespan and promotes increased longevity in aging mice, which suggests that psilocybin may be a potent geroprotective agent.
