Summary: People who go through menopause before the age of 40 are more likely to encounter mental collapse than those who go through menopause after the age of 50. Even after controlling for depression and other factors, the conclusions, based on horizontal information from almost 5, 000 people, suggest that first menstruation may be an independent risk factor for dementia.
Hormone replacement therapy did not have a major cognitive impact, despite women who had menopause after achieving better scores on storage and orientation tests than men. The study strengthens the growing body of research showing that sex-specific elements influence dementia risk and may advise upcoming prevention strategies.
Important Information:
- First Menopause Risk: People who went through menopause before the age of 40 reported worse mental outcomes than those who followed menopause after 50.
- Hormone replacement therapy did not improve mental performance in this review.
- Insight on Sex-Specific Insight: People who went through menopause had higher mental performance than men, highlighting different risk profiles.
Tohoku University is the cause
People who went through menopause before the age of 40 had worse mental result than people who went through menopause after the age of 50, according to a team of researchers from the Tohoku University Graduate School of Medicine and the Tokyo Metropolitan Institute of Medical Science.
When assessing their victim’s risk of dementia, this getting may be helpful for professionals.
These findings were published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association on April 15, 2025.
Because memory affects people in a disproportional way across the globe, the research team made the decision to investigate this link, which may point to a possible risk factor for women.
In addition, premature menopause is linked to a higher risk of depression in after life, which is a known risk factor for dementia. However, there is little empirical research on how earlier acne affected the development of depressive ailments and mental performance.
The group classified menopausal years into three categories: <, 40, 40-49, and 50 years using information from the English Longitudinal Study of Ageing.
In terms of arrangement, fast and delayed remember, and rhetorical fluency, the investigation included 4, 726 ladies and 4, 286 people.
After adjustment of the team’s foundation customizable risk factors for memory, the group examined the relationship between sex, menstruation, and cognitive functioning two years later.
Lead author Miharu Nakanishi ( Tohoku University Graduate School of Medicine ) states,” We want to rule out as many other modifiable risk factors for dementia as possible when looking for associations.”
We had to adjust for this risk because early menopause raises the risk of depression and finally delirium, so we had to check for it to see if early menopause in itself was a strong risk factor.
Menopause at <, 40 years, compared to 50 years, was significantly associated with worse 2-year follow-up preference, as well as quick and delayed remember after controlling for foundation outcome measures and other variables ( such as additional customizable dementia risk factors ).
Women who went through menopause at the age of 50 really had greater cognitive functioning than the menopause group’s counterparts. Cognitive function was not a function of hormone replacement therapy ( HRT), a method of reducing menopausal symptoms.
The results suggest that first menopause-experienced women may be a high-risk team for mental decline in their own sex. Further investigation is necessary to understand the underlying mechanisms of the connection between female hormone levels and mental function.
Understanding this connection in-depth may help us develop solutions that can defy the onset of dementia in at-risk people, Nakanishi says.
About this information about menopause and consciousness research
Author: Public Relations
Source: Tohoku University
Contact: Public Relations – Tohoku University
Image: The image is credited to Neuroscience News
Classic research: Free of charge.
Miharu Nakanishi and others ‘” Menopause at an Early Age Can Cause Cognitive Decline.” Dementia and Alzheimer’s
Abstract
Menopause at a Young Age Is Cause Mental Decline to Get More Exaggerated
INTRODUCTION
There is little research on whether menopause affects aging mental performance pathways linked to increased depressive symptoms. We looked at the vertical relationship between menopause, depressive symptoms, and 2-year follow-up mental function.
METHODS
We classified ovulation into three groups using data from the English Longitudinal Study of Ageing: 40, 40 to 49, and 50 times. Using multilevel board data analysis to represent age trajectories, the review included 4 726 women and 4286 men.
RESULTS
Later menopause ( >50 years ) was significantly related to fewer depressive symptoms and better cognitive functioning than earlier menopause ( <,  , 40 years ). People had significantly less depressive symptoms and poorer thinking than women who went through menopause afterwards.
DISCUSSION
After accounting for foundation depressive symptoms, thinking, and lifestyle factors, earlier menopause was considerably associated with worse 2-year follow-up consciousness. Women who go through first menstruation should be a sex-specific high-risk group for dementia risk reduction strategies.
