Summary: New research reveals that genetics play a major role in determining when babies begin walking, accounting for about 25% of the variation in this milestone. In a study analyzing data from over 70,000 infants, scientists identified 11 genetic markers linked to the timing of first steps.
These genetic influences also connect to broader aspects of development, such as brain structure, ADHD risk, and educational attainment. While environmental factors still matter, the findings suggest that walking later within the typical range is often due to natural genetic variation, not parental error or developmental concerns.
Key Facts:
- Genetic Influence: About 25% of differences in walking age are linked to genetics.
- Shared Development Links: Genes tied to walking are also connected to brain development and learning traits.
- Late Walking Not Always Negative: Later walking was genetically linked to lower ADHD risk and higher education potential.
Source: University of Surrey
The age at which babies take their first steps is strongly influenced by their genes, according to new research from the University of Surrey.
In the first study of its kind, scientists analysed the genetic information of more than 70,000 infants.
They identified 11 genetic markers influencing when babies start walking, thus offering multiple targets for future in-depth biological investigation.
In a paper published in Nature Human Behaviour, the study found that genetics accounts for about a quarter of the differences in when children take their first steps.
For years, researchers knew that environmental factors could influence when babies begin to walk, but this new finding shows that genetics also has a major impact.
It suggests that, just like with other traits such as height, some children may naturally start walking earlier or later because of their genetic propensity.
Professor Angelica Ronald, senior researcher on the study from the University of Surrey, said:
“Most babies take their first step sometime between ages 8 months and 24 months, so it is a wide window in which this exciting milestone happens. It is a big moment for both parents and baby; it symbolises a new phase in a child’s life.
Dr Anna Gui, an author of the study and a researcher at the University of Rome Tor Vergata and Birkbeck, University of London said:
“Until now, we didn’t understand what causes the wide differences between children in when they take their first step. Parents might often worry that walking early or late is a bad sign or that they have done something wrong. We see that genetics play a considerable role in influencing the timing of this milestone.”
Walking isn’t just a key milestone in the development of a child, but it is connected in terms of genetic influences with many other important aspects of human development.
The study found that the genetic factors influencing when children take their first step are partly the same genetic factors that influence brain development including the amount of folding and ridges in the outer surface of the brain (the “cortex”).
Moreover, walking later within the typical range was linked genetically with less chance of developing ADHD. Finally, the study showed that relatively later onset of walking was influenced by some of the same genes involved in higher educational attainment.
Professor Angelica Ronald said:
“It is exciting to be able to discover the genes that influence when children learn to walk. Starting to walk independently is a major milestone for young children. We hope these new genetic findings can advance fundamental understanding about the causes of walking and be used to better support children with motor disorders and learning disabilities.
“While parents should still see their GP if they are concerned, a slightly later start is not always a sign of problems. There is a lot of variety in when children take their first step on their own.”
Led by scientists in the UK, the study was made possible through a large collaboration with scientists in the UK, Netherlands and Norway, and through UK and international funding including from the Simons Foundation for Autism Research Initiative.
About this genetics and neurodevelopment research news
Author: Melanie Battolla
Source: University of Surrey
Contact: Melanie Battolla – University of Surrey
Image: The image is credited to Neuroscience News
Original Research: Open access.
“Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry” by Angelica Ronald et al. Nature Human Behavior
Abstract
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry
Age at onset of walking is an important early childhood milestone which is used clinically and in public health screening.
In this genome-wide association study meta-analysis of age at onset of walking (N = 70,560 European-ancestry infants), we identified 11 independent genome-wide significant loci.
SNP-based heritability was 24.13% (95% confidence intervals = 21.86–26.40) with ~11,900 variants accounting for about 90% of it, suggesting high polygenicity. One of these loci, in gene RBL2, co-localized with an expression quantitative trait locus (eQTL) in the brain.
Age at onset of walking (in months) was negatively genetically correlated with ADHD and body-mass index, and positively genetically correlated with brain gyrification in both infant and adult brains.
The polygenic score showed out-of-sample prediction of 3–5.6%, confirmed as largely due to direct effects in sib-pair analyses, and was separately associated with volume of neonatal brain structures involved in motor control.
This study offers biological insights into a key behavioural marker of neurodevelopment.
