Summary: According to a recent review of human and animal studies, obstructive sleep apnea ( OSA ) contributes to significant memory loss, especially in visual and verbal working memory. Important characteristics of OSA, including periodic ischemia and sleep fragmentation, impair memory and cognition, cause brain inflammation, oxidative stress, and cerebral injury.
With biomarkers like the Oxygen Desaturation Index providing quantifiable perspective, the intensity and frequency of OSA are clearly related to poor memory performance. Experts advocate for better diagnostics and emerging treatments to address this underrecognized cerebral effects while CPAP continues to be the mainstay of treatment.
Important Information:
- Biological Damage: OSA causes neural dysfunction, reactive strain, and neuroinflammation.
- Mental Correlation: The severity of memory impairment is related to OSA intensity and duration.
- Treatment Gaps: CPAP is effective, but new tests and treatments are required for complete mental security.
Origin: Marshall University
A new review published in Sleep Medicine Reviews finds that obstructed sleep apnea ( OSA ), which is frequently linked to cardiovascular and metabolic diseases, also contributes significantly to memory loss.  ,
Researchers from Shanghai Jiao Tong University School of Medicine and Marshall University Joan C. Edwards School of Medicine reviewed research from human and animal experiments that demonstrated that OSA people frequently have noticeable storage difficulties, particularly in terms of visual and verbal working storage.
They report that intermittent hypoxia ( IH) and sleep fragmentation ( SF ) are key biological processes that contribute to cognitive decline, including neuroinflammation, oxidative stress, neuronal injury, altered synaptic plasticity, and blood-brain barrier dysfunction.
Poorer memory performance is directly related to disease severity and duration, with oxygen desaturation index ( ODI) scores showing a correlation with impairment.  ,
The authors point to the need for additional therapies and more precise diagnostic tools to identify and manage OSA-related memory dysfunction, despite continuous positive airway pressure ( CPAP ) therapy remaining the most effective method for protecting cognitive function.
First changes that are spotted by mental imaging, EEG, and body biomarkers may serve as emerging indicators of mental decline.  ,
Drs. and Drs. co-authored the evaluation. Shanghai Jiao Tong University, Xiaoman Zhang, Huajun Xu, and Shankai Yin, along with Drs. Abdelnaby Khalyfa and David Gozal of Marshall University.
Dr. Zhang worked with Khalyfa and the team to create this evaluation essay after finishing a six-month research professor programme in Khalyfa’s laboratory at Marshall University.  ,
The authors also provide an update on upcoming research projects that include the impact of gut microbiotes, hereditary factors, and genetic changes on OSA-related memory loss. They suggest that multifaceted medical profiling might help with the creation of personalized treatment plans.  ,
Funding: The Joan C. Edwards School of Medicine at Marshall University, the National Institutes of Health ( HL166617, HL169266 ), and the Ministry of Science and Technology of the People’s Republic of China (STI2030-Major Projects 2021ZD0201900 ).  ,
About this information about storage and sleeping disruption
Author: Sheanna Spence
Source: Marshall University
Contact: Sheanna Spence – Marshall University
Image: The image is credited to Neuroscience News
Start access to original research.
Xiaoman Zhang and as.,” Obstructive sleep apnea and storage impairments: Clinical description, treatment strategies, and mechanisms.” Rest Healthcare
Abstract
Obstructive sleep apnea and ram loss: clinical characteristics, treatment approaches, and mechanisms
OBS is a condition that affects the vascular, physiological, and neurological systems.
However, the interactions between OSA, action results, and underlying channels are not well understood.
This review summarizes recent developments in OSA-induced storage impairments, including medical description, therapy strategies, and systems.
Major memory loss, including working memory loss from both visual and verbal sources, may be present in OSA patients.
Complex, multifactorial, and poorly understood, and need more research, are the underlying mechanisms that account for OSA-related memory impairment.
Learning and memory function is most likely brought on by oxidative stress, neuroinflammation, neuronal damage, neuronal plasticity, and brain-brain barrier dysfunction, as observed under exposure to intermittent ischemia and sleep fragmentation.
Continuous positive airway pressure therapy can significantly improve OSA sufferers ‘ memory loss.
Other therapies are emerging, but they must become thoroughly tested in order to improve mental function.
For correct diagnosis and clinical description of cognitive deficits in OSA patients, medically, reliable, and objective diagnostic tools are required.
New directions for analysis are emerging from the difficult connections between the gut-brain axis, the genetic environment, biological sensitivity, and OSA-induced memory impairments.
Advances in accuracy medicine can be made by identifying medical phenotypic clusters to anticipate and handle OSA-related memory deficits.
