One protein restores the nervous system’s wiring and causes panic.

Summary: Researchers have uncovered how losing the autism-linked gene PTEN in a specific set of inhibitory neurons reshapes brain circuits tied to fear and anxiety. Using advanced circuit-mapping techniques, they found that deleting PTEN in somatostatin-expressing neurons of the amygdala disrupted local inhibition by 50% while strengthening excitatory input from...

Exercise Evidence-Based to Improve Children’s Mental Health

Summary: A massive analysis of over 375 trials shows that structured exercise significantly reduces depression and anxiety in children and teens. Low-intensity resistance activities like light weights were most effective for easing anxiety, while moderate mixed-mode programs worked best for depression, especially when lasting under 12 weeks.The strongest benefits were...

How Synapses Strengthen While We Rest: How Sleep Learning Works

Summary: New research reveals how synaptic connections in the cerebral cortex can strengthen during sleep, offering insight into how the brain continues learning even while we rest. Using computer simulations, researchers demonstrated that synaptic activity during sleep follows known “synaptic learning rules” when neural activity reaches specific thresholds.This means that...

Alternating Brains Could Increase Depression Return Chance

Summary: Even after symptoms subside, people who’ve experienced depression may retain a heightened sensitivity to punishment and negative feedback. A new study found that the brain’s habenula—key to processing aversive signals—remains hyperactive in those with remitted depression, particularly during the anticipation of unpleasant outcomes.These individuals also showed reduced connectivity between...