Summary: According to research, dementia has genetic risk factors that are more prevalent in men than women, including bipolar disorder and significant depression. This new research analyzed over 3, 000 people, and it found that gender-based hereditary scores for several psychiatric disorders have different effects on psychosis risk.
These findings demonstrate how crucial it is to take into account gender disparities when studying the genetic basis of mental illnesses. The results opened new pathways for individualized techniques to the prevention, treatment, and care of medical conditions.
Important Information:
- Bipolar disorder and depression share genetic risk factors with dementia.
- People are more prone to psychotic disorders than females.
- These observations might lead to more individualized medical care.
Origin: University of Barcelona
A pioneering study led by a team of researchers from the University of Barcelona and the Centre for Biomedical Research in the , Mental Health , Network ( CIBERSAM ) has been published. It examines important findings in the field of genetic psychiatry from the perspective of separate gender analysis.
Second, the report confirms that schizophrenia and other medical problems, such as bipolar disorder and major depression, share a genetic vulnerability.
In contrast, and in an innovative way, the study shows that this is more significant in men than in girls with dementia.
This study, published in the journal , European Neuropsychopharmacology, was co-led by faculty Bárbara Arias and Araceli Rosa, from the University of Biology and the Institute of Biomedicine of the University of Barcelona ( IBUB), and CIBERSAM. The study’s first authors are Sergi Papiol, a member of CIBERSAM and researcher at the Max Planck Institute of Psychiatry in Munich ( Germany ), and Marina Mitjans ( UB-IBUB-CIBERSAM ).
In this review, the writers analyzed a test from CIBERSAM that included 1826 individuals with schizophrenia and 1372 power patients. The purpose of the study was to examine how polygenic scores ( PGS ) for schizophrenia, bipolar disorder, and major depressive disorder affect the prevalence of psychotic disorders, and how these correlations differ between men and women.
According to Marina Mitjans, the first author of the study and a member of the UB’s Department of Genetics, Microbiology and Statistics and the Hospital Sant Joan de Déu de Barcelona ( HSJD), “our results support the hypothesis that there are common genetic factors that contribute to the risk of developing these disorders.”
Additionally, the findings of this study point to differences between men and women in biological vulnerability to psychotic ailments, which may have important implications for understanding the gender differences observed in occurrence, clinical assessment, and treatment response.
According to Bárbara Arias, a part of the UB’s Department of Evolutionary Biology, Ecology, and Environmental Sciences and co-principal inspector of the G08 cluster of CIBERSAM, “our research emphasizes the importance of taking into account gender differences in genomic studies to develop more personalized approaches in prevention, diagnosis, and treatment in scientific exercise.”
The study’s principal researchers concur that” this study is an example of the power of interdisciplinary collaboration between CIBERSAM groups to advance the understanding of complex mental disorders.”
About this information about genetics and research in mental health
Author: Rosa Martínez
Source: University of Barcelona
Contact: Rosa Martínez – University of Barcelona
Image: The image is credited to Neuroscience News
Original Research: Open access.
” In psychotic disorders, shared vulnerability and sex-dependent polygenic burden are present.” by Bárbara Arias et al. European Neuropsychopharmacology
Abstract
In psychotic disorders, shared vulnerability and sex-dependent polygenic burden are present.
Evidence points to a remarkable genetic susceptibility link between psychiatric disorders. However, sex-dependent differences have been less studied.
We explored the contribution of schizophrenia (SCZ), bipolar disorder ( BD ) and major depressive disorder ( MDD ) polygenic scores ( PGSs ) on the risk for psychotic disorders and whether sex-dependent differences exist ( CIBERSAM sample: 1826 patients and 1372 controls ).
All PGSs had strong psychosis connections. According to gender-specific analyses, males and females had significantly higher risk for psychotic disorders than females.
Our findings demonstrate sex-dependent differences in the vulnerability to psychotic disorders and confirm the shared genetic architecture among psychotic disorders.
