Summary: New research shows that the time of day when blood tests are taken considerably impacts the rates of Alzheimer’s indicators, including p-tau217, which is essential for early treatment. The morning and evening diagnostic amounts were found to be the lowest and highest, suggesting that schedule may have an impact on memory diagnosis and monitoring.
Experts recommend standardizing heart sampling times to improve the accuracy of Alzheimer’s diagnosis and monitoring. This finding opens up new strategies for knowing how regular melodies affect brain function.
Important Information:
- Alzheimer’s indicators, such as p-tau217, fluctuate based on the time of morning.
- The day marker levels were the lowest and evening biomarker levels reached their highest levels.
- Improved diagnostic accuracy may be achieved by standardizing the day’s blood test times.
Origin: University of Surrey
According to new study led by the University of Surrey, the day of the week when blood is taken you affect the results of delirium diagnostic tests.  ,  ,
Researchers discovered that the biomarkers used to identify Alzheimer’s, including a encouraging marker for an earlier diagnosis of the situation, varied considerably depending on the day. When individuals woke up, diagnostic rates were at their lowest and highest in the evening.  ,  ,
The p-tau217 marker, which may help with early diagnosis of dementia, showed great distinctions depending on the time of morning. Researchers discovered that the variations between morning and evening levels were comparable to those seen in people whose gentle remembrance issues worsen over the course of a season.  ,
Dr Ciro la Monica, research fellow at the Surrey Sleep Research Centre at the University of Surrey and first creator of the release, said:  ,  ,
This work highlights the importance of taking into account the time of day when taking scientific clinical tests and how varying trial periods may affect an individual’s medical image. The diagnosis of dementia and monitoring disease progression may be made more appropriate by standardizing the day of a sample taken.
The study looked at 38 participants living with mild Alzheimer’s, their caregivers and health controls while they were residents at the Surrey Sleep Research Centre, which is part of the UK Dementia Research Institute’s ( UK DRI ) Care Research &, Technology Centre.  ,
The participants had their heart taken every three hours for 24 hours rather than just one blood sample, as is typical of medical practices.  ,  ,
Four out of five determined indicators (p-tau217, Aβ40, Aβ42, and NfL ) showed levels of volatility throughout the day. Just GFAP revealed no statistically significant variation.  ,
Now, it is not known what is driving these time-of-day distinctions.  , It does relate to rest and sleep-related decline in the production or certification of these markers from the mind to the flow, meals, position, activity, or daily mechanisms.
The results, however, suggest that the timing of specimen collection is important for blood biomarker execution and interpretation in memory research and care. These observations, in general, suggest that sequencing should be conducted in accordance with the picking schedule or at least recorded.  ,  ,  ,
Professor Derk-Jan Dijk, Director of the Surrey Sleep Research Centre, UK DRI Group Leader and top author of the release, said:  ,  ,
Studies on the origins of the circadian rhythm shows that almost all physiology and mind function parameters change depending on the time of day. This study shows that translating this basic knowledge to the area of dementia research holds great promise for a better understanding, diagnosis and treatment of Alzheimer’s” . ,  ,  ,
About this Alzheimer’s disease study information
Author: Dalitso Njolinjo
Source: University of Surrey
Contact: Dalitso Njolinjo – University of Surrey
Image: The image is credited to Neuroscience News
Original Research: Start entry.
“P-tau217 and different heart indicators of memory: variance with time of day” by Ciro la Monica et cetera. Translational Psychiatry
Abstract
P-tau217 and different heart indicators of memory: variance with time of day
Plasma biomarkers of dementia, including phosphorylated tau (p-tau217 ), offer promise as tools for diagnosis, stratification for clinical trials, monitoring disease progression, and assessing the success of interventions in those living with Alzheimer’s disease.
But, now, it is unknown whether these memory diagnostic amounts vary with the time of day, which could have implications for their therapeutic value.
In two protocols, we studied 38 participants ( 70.8 ± 7.6 years, mean ± SD ) in a 27-h laboratory method with either two samples taken 12 h off or 3-hourly body sequencing for 24 h in the presence of a sleep–wake period.
The study population comprised people living with mild Alzheimer’s disease ( PLWA,  , n = 8 ), partners/caregivers of PLWA ( n = 6 ) and cognitively intact older adults ( n = 24 ). Single-molecule array technology was used to measure phosphorylated tau (p-tau217 ) ( ALZpath ), amyloid-beta 40 ( Aβ40 ), amyloid-beta 42 ( Aβ42 ), glial fibrillary acidic protein, and neurofilament light ( NfL ) ( Neuro 4-Plex E).
Analysis with a linear mixed model ( SAS, PROC MIXED ) revealed a significant effect of time of day for p-tau217, Aβ40, Aβ42, and NfL, and a significant effect of participant group for p-tau217. For p-tau217, the lowest levels were observed in the morning upon waking and the highest values in the afternoon/early evening.
The magnitude of the diurnal variation for p-tau217 was similar to the reported increase in p-tau217 over one year in amyloid-β-positive mild cognitively impaired people.
Currently, the factors driving this diurnal variation are unknown and could be related to sleep, circadian mechanisms, activity, posture, or meals.
Overall, this study suggests that the day of sample collection may be important for the use and interpretation of plasma biomarkers in dementia research and care.
