Summary: A recent study examined how gut bacteria and food molecules communicate, revealing why people respond to different diets. By examining 150 eating materials, researchers found that these substances is reshape gut microbes in some people, while having little effect in people.
This development may help develop individualized nutrition plans to maintain health risks. The results offer a deeper understanding of the colon microbiome’s position in health and illness.
Important Facts:
- In various people, gut microbes react differently to the same foods molecules.
- The research mapped 150 foods compounds ‘ effects on colon microbes.
- This study might lead to better health-related personalized nutritional advice.
Origin: Yale
” Gut wellbeing” is a growing term for chefs and nutritionists alike—and with good reason. The billions of bacteria and bacteria that exist in our colon are implicated in a number of health and disease processes.
The Yale Microbial Sciences Institute’s researchers have made a significant step forward in developing individualized nutrition that is based on specific gut health needs.
The test of Andrew Goodman has created the first comprehensive map that depicts how the molecules in particular foods communicate with our distinctive gut bacteria.
Their conclusions are  , published , in the journal , Cell.
The professionals sought to understand why different people react differently to the same foods by expanding on earlier studies looking at medical medicines and gut bacteria.
Elizabeth Culp, a former doctoral fellow at the Goodman Lab and the study’s first artist, said,” We know that eating is a huge part of our wellbeing and shapes our microbiome.
While a large body of work has described the effects of “macronutrients” quite as grain on our , gut microbes, surprisingly little is known about how other little molecular components in food generate health problems.
” Aside from empirical example in the , scientific literature, data is limited regarding which diet changes people can make to help them manage , chance factors , for diseases like diabetes or malignancy”, said Culp.
” It is possible that this is because our microbiota react differently to the same substances that are present in food,” the author speculates.
The researchers designed a comprehensive image of the interactions between , little molecules , in our foods and diverse bacteria in the gut.
The research is among the first to describe the specific microbial genes that control the metabolic processes of eating substances and the methods by which eating substances affect our microbes.
Using liquid chromatography-mass spectroscopy at the Yale West Campus Analytical Core, the researchers combined different atoms with gut bacteria to produce development models and maps for around 150 diet” xenobiotic” compounds.
The Yale Center for Genome Analysis ‘ sequencing enabled the team to determine how much of the composition of human gut communities has changed.
” We were surprised by the level of variability”, said Goodman, who is the C. N. H. Long Professor and Chair of Microbial Pathogenesis, and Director of the Microbial Sciences Institute ( MSI).
The same dietary supplement, according to the article,” could fundamentally alter some people’s gut microbiomes without having any significant impact on the microbiomes of others.”
The molecular map provides a mechanism for how these different responses differ, showing how a dietary supplement affects gut microbe growth and how the microbial community alters that compound’s metabolic state.
Predicting how an individual responds to a given food—and ultimately how this affects their , health—remains difficult. But the findings offer a foundation to understand how metabolic reactions vary between people and how these differences shape the growth of “good” or “bad”  , bacteria , in our gut.
According to Culp, who is currently a scientist at Empress Therapeutics in Boston,” correlating a microbiome to a molecule in our food and how these genes are different between different people’s microbiomes can start to make sense.”
” This is the first step in the development of personalized nutrition strategies that include personalized dietary recommendations.”
About this news about diet and microbiome research
Author: Jon Atherton
Source: Yale
Contact: Jon Atherton – Yale
Image: The image is credited to Neuroscience News
Original Research: Open access.
” The microbial transformation of dietary xenobiotics influences gut microbiome composition,” by Elizabeth J. Culp and al. Cell
Abstract
The composition of the gut microbiome is influenced by the microbial transformation of dietary xenobiotics.
Diet is a significant factor in the composition of the gut microbiome, and variations in how diet-microbiome interactions interact may affect how well their health is affected.
To mechanistically understand these relationships, here we map interactions between ∼150 small-molecule dietary xenobiotics and the gut microbiome, including the impacts of these compounds on community composition, the metabolic activities of human gut microbes on dietary xenobiotics, and interindividual variation in these traits.
Microbial metabolism can toxify and detoxify these compounds, producing emergent interactions that explain community-specific remodeling by dietary xenobiotics.
We find the gene and enzyme responsible for the detoxification of resveratrol, a type of dietary xenobiotic, and demonstrate that this enzyme contributes to interindividual variation in community remodeling caused by resveratrol.
Together, these findings systematically examine the interactions between dietary xenobiotics and the gut microbiome and link toxification and detoxification to interpersonal differences in microbiome responses to diet.
