Summary: New research shows that dormant, or “zombie”, body tissue does accelerate aging throughout the body. These cells, when transplanted into a preliminary model, led to the loss of muscle function and brain function, which in turn led to senescence in various organs.
This finding provides new insight into the link between body conditions and overall decline, suggesting that skin aging may contribute to broader widespread maturity. The research supports aging prevention approaches that target senescent cell while also addressing both physical and cognitive health.
Important Information:
- Sensitive skin tissue can cause various tissues and systems to deteriorate more quickly.
- The spread of these cell has an impact on brain function and muscle function.
- The study supports skin-senescent cell anti-aging strategies.
Origin: Mayo Clinic
Scientists at the Mayo Clinic discovered that non-dividing “zombie” cells accumulate in the body as people get older and have an impact on how old are in other body parts.
Their most recent research revealed that transplanting dormant body cells into a preliminary model revealed that they not only caused that senescence to distribute to other tissues, but also accelerated real decline, affected muscle function, and adversely impacted brain health. This finding points to the possibility that dormant skin cells may cause more extensive, widespread aging.
” This finding is significant because it suggests that dormant cell in the skin—an instrument not usually associated with aging, beyond wrinkles—might become driving broader, structural aging processes.
” These results may likewise help explain the link between , body conditions , and , cognitive decline, offering prospective new channels for addressing both physical and mental deterioration as we age,” says Mayo Clinic scientist João Passos, Ph. D., who is one of the prospect writers on the research,  , published , in , Aging Cell.
Additionally, this study supports anti-aging methods that aim to keep the mind and body in better health for long.
” This study suggests that skin aging may accelerate aging in other organs, highlighting the importance of preventing factors like , sunlight exposure, smoking, drinking and , poor diet , that contribute to premature body aging,” says Ana Catarina Franco, the study’s first author and Mayo Clinic visiting graduate student.
The researchers want to find out whether applying topically to the skin can improve overall health by removing senescent cells from people who have a large number of senescent cells, as well as senolytic drugs, which were first developed at Mayo Clinic and shown to eliminate senescent cells in patients with a high number of senescent cells.
They also plan to do more research to try to understand the mechanisms by which , senescent cells , may spread from the skin to other organs.
About this news from brain aging research
Author: Ana Catarina Franco
Source: Mayo Clinic
Contact: Ana Catarina Franco – Mayo Clinic
Image: The image is credited to Neuroscience News
Original Research: Open access.
Ana Catarina Franco and colleagues ‘ study” Senescent cell transplantation into the skin causes age-related peripheral dysfunction and cognitive decline.” Aging Cell
Abstract
Senescent cell transplantation leads to a cadet’s aging-related cognitive decline and peripheral dysfunction.
Cellular senescence is a well-known cause of cell and tissue aging. Senescent cells have been shown to grow in a number of organs as a result of aging, including the skin. We present a hypothesis that senescent skin cells can spread senescence to far-offical organs, accelerating the onset of systemic aging.
In order to test this hypothesis, we first noticed an increase in several senescence markers in the skin of aging mice. In order to evaluate various age-related parameters, we conducted experiments in which senescent fibroblasts were transplanted into the dermis of young mice.
Our findings reveal that senescent cells in young mice’s dermal layer cause more proximal and distal host tissues to senescence, as well as frailty, and impaired musculoskeletal function.
Additionally, there was a significant decline in cognitive function, concomitant with increased expression of senescence-associated markers within the hippocampus brain area.
These findings support the idea that the accumulation of senescent cells in the skin can have dispersed effects on other organs, including the brain, which might explain connections between skin-related illnesses and brain-related diseases and contribute to physical and cognitive decline as a result of aging.
