Summary: Microglia, the brain’s immune cells, play vital roles in clearing toxins and maintaining neuronal health but can also contribute to neurodegenerative diseases if overactive. New research reveals sex-based differences in how adult male and female microglia respond to the enzyme inhibitor PLX3397, a common tool in microglial research.While male...

Summary: A new study has uncovered a direct link between somatic mutations and epigenetic modifications, challenging established views on aging. Researchers found that random genetic mutations drive predictable changes in DNA methylation, offering new insights into the relationship between mutation accumulation and epigenetic clocks.This suggests that epigenetic changes may track,...

Summary: A study analyzing data from over 130 million individuals found that antibiotics, antivirals, vaccines, and anti-inflammatory medications are associated with a reduced risk of dementia. This supports the idea that infections and inflammation contribute to dementia and highlights the potential of repurposing existing drugs for prevention or treatment.While some...