Summary: A research that looked at the effects of prenatal exposure to synthetic cannabinoids on animals found that the drug causes the drug’s children to experience long-term health problems. Female rats had more heart problems like hypertension and hypertension, whereas female rats had more responsiveness to CO2 and were more prone to panic-like habits.
Additionally, the study found that men ‘ sleep quality was poor, and that females had a lighter effect. These findings highlight the potential hazards of cannabis use while pregnant, with sex-specific effects observed in the sons.
Important Information:
- Men exposed to thc in gestation were more delicate to CO2, linked to panic-like actions.
- Women had more recurrent cardiovascular issues, including hypotension and tachycardia.
- Teenagers ‘ sleep quality decreased more frequently than females ‘ because of frequent awake.
Origin: FAPESP
Researchers found effects of the drug on female rats ‘ offspring, such as increased circulatory problems in women and increased vulnerability to panic attacks in men, and showed that these adverse effects continued into adult after giving the rats a synthetic cbd that activates the same receptors in the brain as pot.
An essay on the research is , published , in the , American Journal of Physiology – Lung Cellular and Molecular Physiology.
The artists draw a cautionary note regarding the use of cannabis for medical or recreational purposes while pregnant following the results.
The study was conducted with , FAPESP’s support , by researchers affiliated with São Paulo State University ( UNESP) and the University of São Paulo ( USP) in Brazil. The same group’s earlier studies have demonstrated the effects of marijuana exposure on young rats and newborns.  ,
We observed long-term changes in animal behavior and, most importantly, cardiac function in womb-exposed wombs. The modifications were different in males and females”, said , Luis Gustavo Patrone, primary author of the article.
The research was part of his PhD study, which was supported by a , fellowship from FAPESP , while he was a graduate candidate at the School of Agricultural and Veterinary Sciences (FCAV-UNESP) in Jaboticabal, São Paulo position, where he is now a , doctoral brother.  ,
The adult subjects ( 80 days old ) analyzed in this most recent trial did not exhibit any changes to baseline respiration, which may be a result of an unidentified compensation mechanism during postnatal development.
One study found that the adult males ‘ respiratory sensitivity to carbon dioxide ( CO2 ) was increased after intrauterine exposure to the cannabinoid, which was not different from one study to the next. The same effect was observed in the ladies.
” People may experience panic attacks caused by shortness of breath and a fake suffocation concern due to their increased sensitivity to CO2 .” In the animals in our study, this type of actions consisted of attempts to escape from the room”, said , Luciane Gargaglioni, next author of the article and a professor at FCAV-UNESP.
Sleeping and circulatory health
The researchers also examined the effects of exposure to the cbd during fetal development on the ability to develop cardiovascular function in the creatures, finding that females with hypertension and tachycardia are more often found to have these symptoms.
Males, who frequently experienced awake shows, experienced the worst sleep quality. ” They slept less, considering the sum total of slumber bouts”, Patrone said. Sleep excellent also deteriorated in women, but less significantly.
Gargaglioni said,” Most scientific studies only assess parameters for males, assuming that the findings will be acceptable for both sexes, but in our laboratory we often make the distinction, and the responses are frequently very various, as in this study.”
The presence of sex hormones may be a factor in the differences between male and female benefits. In women, estrogen is known to be chemopreventive and may block the harmful results of the thc on their brains.
Additionally, males are known to develop their mammalian respiratory system more gently, occurring primarily when testosterone levels rise during masculinization and the development of sexual organs.
The early development of the bronchi and the brain regions responsible for controlling pulmonary function definitely made the males more vulnerable to the negative effects of the cannabinoid.
The authors point out that the maternal maternal behavior that was observed did not change in the paternal care of the sons as a result of the marijuana contact during pregnancy compared to the control group, which did not receive the substance.  ,
About this news from neurodevelopment research
Author: Heloisa Reinert
Source: FAPESP
Contact: Heloisa Reinert – FAPESP
Image: The image is credited to Neuroscience News
Original Research: Open access.
Luis Gustavo Patrone and colleagues ‘” Long-term effects on cardiorespiratory and behavioral responses in male and female rats exposed to cannabinoid” is a paper that discusses this topic. American Journal of Physiology: Lung Cellular and Molecular Physiology
Abstract
Cannabinoid exposure before pregnancy has long-term effects on behavioral and cardiorespiratory responses in male and female rats
Development of the respiratory system can be affected by the use of drugs during pregnancy, as the prenatal phase is highly sensitive to pharmacological interventions, resulting in long-term consequences.
The harmful effects of external cannabinoids may be related to a relationship between negative interference in the development of the central nervous system, cardiorespiratory system, and behavioral disorders.
Nevertheless, the impact of external cannabinoids on cardiorespiratory network development, chemosensitivity, and its future consequences in adulthood is still unclear. We evaluated the effects of prenatal exposure to a synthetic cannabinoid ( WIN 55, 212-2, 0.5 mg·kg−1·day−1 ) on the cardiorespiratory control and panic-like behavior of male and female rats in adulthood.
Exogenous cannabinoid exposure during pregnancy caused a sex-dependent difference in breathing control. Specifically, males showed increased chemosensitivity to CO2 , and O2, whereas females exhibited decreased sensitivity.
Prenatally treated males and females were more susceptible to hypertension and tachycardia under adverse environmental conditions, and altered cardiovascular control was apparent.
Additionally, males who received WIN were more likely to fragment their sleep patterns, whereas females were more sensitive to CO2 and had anxiolytic and panicolytic behavioral responses.
No neuroanatomical alterations, such as changes to CB1 ’s expression, brainstem receptors, or catecholaminergic and serotonergic neurons, were found, though.
These findings demonstrate that sex-specific, long-lasting effects on the cardiorespiratory system and behavioral responses in adulthood result from external interference in cannabinoid signaling during fetal development.
